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目的 探讨短效催眠药佐匹克隆和三唑仑对人体前庭性错觉的影响。方法 8名受试者,采用三阶段交叉双盲给药方法,分别交叉服用三唑仑(0.25mg)、佐匹克隆(10mg)和安慰剂(每次间隔1周),在服药前2h及服药后2、4、6、8、10h分别进行一组前庭性错觉测试,包括旋转后错觉和科里奥利加速度错觉,记录错觉形态与错觉持续时间。结果 与安慰剂比较,服用佐匹克隆和三唑仑能显著延长旋转后错觉和科里奥利错觉的持续时间,但持续时间不长,在服药后2h达到最大效应,服药6h后即消失。佐匹克隆与三唑仑相比,差别无显著性意义,药物对错觉形态也未有明显影响。结论 佐匹克隆及三唑仑对人体前庭性错觉具有一定的影响,但这种影响持续时间较短,在服药6h后均已消除,对人体的空间定向无残留后遗效应。
Objective To investigate the effect of short-acting hypnotics zopiclone and triazolam on human vestibular illusion. Methods Eight subjects were randomized to three doses of clozapine (0.25 mg), zopiclone (10 mg) and placebo (one week at a time) in a three-phase crossover and double- A group of vestibular illusion tests were performed at 2, 4, 6, 8, 10 and 10 h after taking the medication, including illusion of rotation and Coriolis acceleration, and the duration of illusion and illusion. Results Compared with placebo, zopiclone and triazolam significantly prolonged the duration of post-rotation delusion and Coriolis illusion, but did not last long, achieving maximum effect at 2 hours and disappearing after 6 hours. Zopiclone compared with triazolam, the difference was not significant, the drug has no significant effect on the optical illusion. Conclusion Zopiclone and triazolam have certain effects on the vestibular illusion of the human body. However, this effect has a short duration and has been eliminated 6h after taking the drug. There is no residual effect on the spatial orientation of the human body.