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1982年是Koch发现结核杆菌的百年纪念,医务工作者经过这一个世纪的大量探索和实践,已使结核病的疫情显著改善,特别是从50年代起,下降迅速,如以死亡率为例在1950年以前,世界上没有一个国家的结核病死亡率在10/10万以下,而根据1967～77年全球性调查,五大洲已有不少国家低于2/10万,目前少数国家如美国已小于1/10万。从结核病疫情下降与化疗的广泛应用和日趋完善之间的密切相关,使化疗在控制结核病工作中的作用,日益受到重视,公认为防痨的主要武器。但是,化疗发展是经过艰辛历程的,从本世纪初至40年代,进行过金制剂、磺胺类、砜类等抗结核
1982 was the centennial anniversary of Koch’s discovery of Mycobacterium tuberculosis. After a century of extensive exploration and practice, medical workers have made significant improvements in the epidemic of tuberculosis, especially since the 1950s, as shown by the death rate in 1950 Years ago, no country in the world had a TB death rate below 10/10 million. According to the global survey conducted in 1967-77, many countries on the five continents have seen less than 2 / 100,000 deaths. At present, a few countries such as the United States have been less than 1/10 million. The close relationship between the drop of tuberculosis epidemic and the extensive application of chemotherapy and the perfection of chemotherapy make the role of chemotherapy in the control of tuberculosis increasingly recognized and regarded as the main weapon against tuberculosis. However, the development of chemotherapy is through a difficult process. From the beginning of this century to the 1940s, anti-TB drugs such as gold preparations, sulfonamides and sulfones