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采用小鼠腹腔巨噬细胞在含有过氧化低密度脂蛋白（Ｐｏｘ－ＬＤＬ）的培养液中培养，并用巴曲酶（ｂａｔｒｏｘｏｂｉｎ）进行干预，运用透射电子显微镜进行观察，旨在了解巴曲酶对巨噬细胞吞噬ｐｏｘ－ＬＤＬ的影响。研究结果表明；小鼠腹腔巨噬细胞与纯培养剂ＤＭＥＭ正常低密度脂蛋白（ｎ－ＬＤＬ），以及ｎ－ＬＤＬ加巴曲酶培养４小时后，细胞的超微结构与培养前相似，而与Ｐｏｘ－ＬＤＬ一起培养４小时后细胞胞浆内则含大量的脂滴，加入巴曲酶及小鼠腹腔巨噬细胞内脂滴的生成明显加快。结果提示巴曲酶可以增强巨噬细胞对ｐｏｘ－ＬＤＬ的吞噬及降解作用
Mouse peritoneal macrophages were cultured in a medium containing Pox-LDL and treated with batroxobin. Transmission electron microscopy was used to observe the effect of batroxobin The effect of macrophage phagocytosis pox-LDL. The results showed that the ultrastructures of the cells were similar to those before culturing after the mouse peritoneal macrophages were cultured with the pure culture medium DMEM normal low density lipoprotein (n-LDL) and n-LDL plus batroxobin for 4 hours After cultured with Pox-LDL for 4 hours, the intracellular cytoplasm contained a large amount of lipid droplets. The addition of batroxobin and mouse intraperitoneal macrophages significantly accelerated the formation of lipid droplets. The results suggest that batroxobin can enhance macrophage phagocytosis and degradation of pox-LDL