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目的:探讨早期微量喂养联合双歧杆菌四联活菌片对早产低体质量儿喂养不耐受的临床疗效。方法:120例早产低体质量儿随机分为实验组57例和对照组63例,均给予常规治疗。实验组在常规治疗基础上实施早期微量喂养,并口服双歧杆菌四联活菌片每次0.25 g,2次/天,用至出院。结果:喂养不耐受发生率实验组24.56%,对照组41.27%(P<0.05);住院时间实验组(12.27±3.08)d,对照组(13.36±2.89)d(P<0.05);达完全肠道喂养时间实验组(10.28±3.13)d,对照组(12.41±3.42)d(P<0.01);恢复出生体质量时间实验组(8.20±2.90)d,对照组(10.10±2.94)d(P<0.01);蓝光照射时间实验组(2.84±1.15)d,对照组(5.80±2.83)d(P<0.01);两组高胆红素血症发生率比较差异无统计学意义(P>0.05)。结论:早期微量喂养联合双歧杆菌四联活菌片可改善早产儿喂养不耐受状况,能帮助患儿尽快建立完全胃肠喂养,促进早产儿体格生长,减少黄疸治疗时间,缩短住院时间。
Objective: To investigate the clinical efficacy of early micronutrient combined with Bifidobacterium quadriceps enteritidis intolerance to preterm low birth weight infants. Methods: 120 preterm low birth weight children were randomly divided into experimental group 57 cases and control group 63 cases, both given conventional treatment. Experimental group in the conventional treatment based on the implementation of early micro-feeding and oral Bifidobacterium quadruple live tablets 0.25g, 2 times / day, to be discharged. Results: The incidence of intolerance was 24.56% in the experimental group and 41.27% in the control group (P <0.05). The hospitalization time was 12.27 ± 3.08 days in the experimental group and 13.36 ± 2.89 days in the control group (P <0.05) (10.28 ± 3.13) d in control group and 12.41 ± 3.42 (P <0.01) in control group (P <0.01). The time of birth weight recovery in experimental group (8.20 ± 2.90) d and control group (10.10 ± 2.94) d P <0.01). There was no significant difference in the incidence of hyperbilirubinemia between the two groups in experimental group (2.84 ± 1.15) days and 5.80 ± 2.83 days (P> 0.05). Conclusion: Early micronutrient feeding combined with Bifidobacterium quadriceps could improve the feeding intolerance in premature infants. It can help children establish complete gastrointestinal feeding as soon as possible, promote physical growth of premature infants, reduce jaundice treatment time and shorten hospitalization time.