Effects of 12-lipoxygenase and angiotensin Ⅱ on p21,p27 and p57 in rat diabetic glomeruli

• 作 者: 臧崇森
• 机 构: Dept Nephrol,1st Hosp,Jilin Univ,
• 出 处: China Medical Abstracts(Internal Medicine)
• 发表日期: 2017年02期
• 关键词: lipoxygenase hypertrophy osmotic glomerular creased pression Blood urinary block

Objective To investigate the effects of 12-lipoxygenase(12-LO)and angiotensinⅡ(AngⅡ)on the CIP/KIP family of cyclin-dependent kinase inhibitors(CKIs)p21,p27 and p57 related to cell hypertrophy.Methods Mesangial cells were treated with high glucose for 24hours and 48 hours respectively.12(S)-hydroxyeicosa-

Objective To investigate the effects of 12-lipoxygenase (12-LO) and angiotensinⅡ (AngⅡ) on the CIP / KIP family of cyclin- dependent kinase inhibitors (CKIs) p21, p27 and p57 related to cell hypertrophy .Methods Mesangial cells were treated with high glucose for 24hours and 48 hours respectively.12 (S) -hydroxyeicosa-