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①目的探讨喉癌病人血清肿瘤坏死因子（ＴＮＦ）水平的改变及其临床意义。②方法采用ＥＬＩＳＡ法测定３７例喉鳞状细胞癌病人、２５例喉良性疾病病人和４０例正常人血清ＴＮＦ水平。③结果喉癌病人血清ＴＮＦ水平较良性疾病组和正常对照组增高（ｔ′＝５．８２，５．６７，Ｐ均＜０．０１）；以大于正常对照组血清ＴＮＦ的ｘ±２ｓ为阳性，喉癌组阳性率为７５．７％，良性疾病组阳性率为８．０％，两组比较差异有极显著性（χ２＝２４．７２，Ｐ＜０．０１）；喉癌病人血清ＴＮＦ水平与临床分期无关（ｔ＝０．１６，Ｐ＞０．０５）。④结论喉癌病人血清ＴＮＦ水平升高，检测血清ＴＮＦ水平有助于喉癌的诊断。
Objective To investigate the changes of serum tumor necrosis factor (TNF) levels in patients with laryngeal cancer and its clinical significance. 2 Methods ELISA was used to determine serum TNF levels in 37 patients with laryngeal squamous cell carcinoma, 25 patients with benign laryngeal diseases, and 40 normal controls. 3 Results Serum TNF levels in patients with laryngeal cancer were higher than those in benign disease group and normal control group (t’ = 5.82, 5.67, P <0.01); Positive x + 2s was greater than serum TNF in normal control group. The positive rate of the laryngeal cancer group was 75.7%, and the positive rate of the benign disease group was 8.0%. There was a significant difference between the two groups (χ2=24.72, P<0.01); serum TNF in patients with laryngeal cancer The level was not related to clinical stage (t=0.16, P>0.05). 4 Conclusion Serum TNF levels in patients with laryngeal cancer are elevated, and detection of serum TNF levels contributes to the diagnosis of laryngeal cancer.