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目的:运用累积meta分析的方法,评价中西医结合治疗功能性消化不良的临床效果。方法:检索中国期刊全文数据库、万方数据库、中国科技期刊全文数据库、Pubmed、EMbase数据库从2006年6月—2016年6月发表的关于中西医结合治疗功能性消化不良的文献,对总有效率、治愈率按照发表年代先后顺序和样本量大小的顺序进行累积meta分析。结果:24项共4230例功能性消化不良患者符合本研究的纳入标准,最终进行累积分析。累积meta分析显示,中西医结合治疗功能性消化不良总有效率优于对照组,这种优势按发表年代先后顺序累计后,具有时间稳定性;按样本量大小顺序累积后,存在样本量易变性。中西医结合治疗功能性消化不良治愈率优于对照组,这种优势无论按发表年代先后顺序或样本量大小顺序累计后,都不具有稳定性,存在时间和样本量易变性。结论:中西医结合治疗功能性消化不良的临床效果优于单纯西医治疗,但这种优势具有不稳定性,尚需更多大样本、多中心、设计合理的随机双盲对照实验来进一步证实。
Objective: To evaluate the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of functional dyspepsia by the method of cumulative meta-analysis. Methods: The Chinese Journal Full-text Database, Wanfang database, Chinese Science and Technology Journals Full-text Database, Pubmed, EMbase database from June 2006 to June 2016 published on the treatment of functional dyspepsia literature, the total effective rate , The cure rate in accordance with published chronological sequence and sample size cumulative meta-analysis. RESULTS: Totally 4230 patients with functional dyspepsia were eligible for inclusion in this study and were finally analyzed cumulatively. Cumulative meta-analysis showed that the total effective rate of functional dyspepsia treated by combination of TCM and Western medicine was better than that of control group. This advantage was time-stable after accumulating in the chronological order of publication, and was variable after sample size accumulation . Integrative medicine treatment of functional dyspepsia cure rate is better than the control group, this advantage no matter according to the published chronological order or the size of the sample size accumulated, they are not stable, the existence of time and sample size variability. Conclusion: The clinical effect of integrated traditional Chinese and western medicine in treating functional dyspepsia is superior to that of western medicine alone. However, this advantage is unstable and needs more large sample, multicenter and well-designed double-blind randomized controlled trials to further confirm.