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目的探讨Y染色体结构多态与流产、死胎、死产的关系。方法按常规方法制备外周血淋巴细胞染色体标本,G显带后,镜下Y染色体结构异常核型分析。结果 126例受检者共检出Y染色体多态性变异32例,变异检出率为25.4%(32/126)。其中包括大Y染色体27例,异常发生率为21.43%,明显高于普通人群中的发生率,二者相比有显著性差异(P<0.01);del(Y)5例,异常率为3.97%,与已报道在生育男性中Y染色体微缺失发生率一致。结论 Y染色体多态性与其妻习惯性流产、死胎、死产有关。
Objective To investigate the relationship between Y chromosome polymorphism and abortion, stillbirth and stillbirth. Methods Chromosomal specimens of peripheral blood lymphocytes were prepared by conventional methods. After G-banding, the karyotypes of Y chromosome were analyzed. Results Totally 126 cases of Y chromosome polymorphism were detected in 32 cases, the rate of variation was 25.4% (32/126). Including the large Y chromosome in 27 cases, the abnormal incidence was 21.43%, significantly higher than the incidence of the general population, there was significant difference (P <0.01); del (Y) 5 cases, the abnormal rate was 3.97 %, Consistent with the reported incidence of Y-chromosome microdeletions in fertile males. Conclusion Y chromosome polymorphism and his wife habitual abortion, stillbirth, stillbirth.