Highly efficient catalysts derived from planar chiral ferrocenes for asymmetric transfer hydrogenati

• 作 者: 杜向东 戴立信 侯雪龙 夏立钧 唐明华
• 机 构: Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of
• 出 处: Chinese Journal of Chemistry
• 发表日期: 1998年01期
• 关键词: hydrogenation chiral asymmetric Highly catalyzed planar hydroxide instead absolu

Planar chiral ferrocenes 1 and its diastereoisomer 2 were found to be good lig-ands for the ruthenium catalyzed asymmetric transfer hydrogenation of ketones with i-PrOH as hydrogen source under refluxing in the presence of sodium hydroxide. The results showed that the absolute configuration of alcohol seemed to be governed by the central chirality in the oxazoline ring instead of the planar chirality. At a ratio of 1:2 for Ru:ligand, 3000:1 S/C and >100,000/h-1 TOF were observed for acetophenone. For propiophenone 99% yield and 85% e.e. were obtained