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目的探讨紫杉醇联合奥沙利铂治疗晚期消化道恶性肿瘤的效果。方法紫杉醇联合奥沙利铂治疗晚期消化道恶性肿瘤48例,其中胰头癌12例,胆囊癌8例,胃癌16例,结肠癌12例。结果紫杉醇联合奥沙利铂治疗晚期消化道恶性肿瘤,总有效率为(CR+PR)64.6%。其中:CR+PR在胰头癌为8/12,胆囊癌5/8,胃癌12/16,结肠癌6/12。主要不良反应为白细胞下降(85.4%)、脱发(87.5%)、神经毒性(47.9%),无严重过敏反应发生。结论紫杉醇联合奥沙利铂对晚期消化道恶性肿瘤有一定的治疗作用。
Objective To investigate the effect of paclitaxel combined with oxaliplatin in the treatment of advanced gastrointestinal malignancies. Methods Forty-eight patients with advanced gastrointestinal malignancies were treated with paclitaxel and oxaliplatin, including 12 cases of pancreatic head cancer, 8 cases of gallbladder cancer, 16 cases of gastric cancer and 12 cases of colon cancer. Results Paclitaxel plus oxaliplatin in the treatment of advanced gastrointestinal malignancies showed a total effective rate of (CR + PR) 64.6%. Of which: CR + PR in pancreatic head cancer is 8/12, gallbladder cancer 5/8, gastric cancer 12/16, colon cancer 6/12. The main adverse reactions were leukopenia (85.4%), alopecia (87.5%), neurotoxicity (47.9%) and no serious allergic reaction. Conclusion Paclitaxel combined with oxaliplatin has a certain therapeutic effect on advanced gastrointestinal cancer.