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对肝内HDAg阳性的慢性丁型肝炎患者临床资料分析表明:若慢性乙肝患者突然出现急性肝炎样表现或反复发作,并且病情进行性发展为肝硬化者,应考虑合并丁型肝炎病毒感染的可能;患者肝内HDAg持续阳性,常预后不良。免疫病理资料提示:HDAg阳性肝细胞周围常不能见到炎性细胞,尤其是淋巴细胞的包绕;部分含HDAg肝细胞,特别胞浆型的阳性细胞可呈气球样变性或萎缩或坏死,似支持HDV具有直接致病作用的观点。
Analysis of the clinical data of patients with HDAg-positive chronic hepatitis B in the liver shows that if acute hepatitis-like symptoms or recurrent episodes occur in patients with chronic hepatitis B and the disease progressively progresses to cirrhosis, the possibility of infection with hepatitis D should be considered ; Patients with persistent positive HDAg in the liver, often poor prognosis. Immunopathological data suggest that: around the HDAg-positive hepatocytes often can not see inflammatory cells, especially lymphocytes; part of the HDAg-containing hepatocytes, especially the cytoplasm of positive cells may be balloon-like degeneration or atrophy or necrosis, Supports the view that HDV has a direct pathogenic role.