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目的：观察麦滋林－ｓ加雷尼替丁治疗消化性溃疡的疗效。方法：经胃镜确诊的消化性溃疡８７例，随机分为治疗组（男性４０例，女性７例，年龄３８±ｓ１４ａ）餐前冲服麦滋林－ｓ０．６７ｇ，ｔｉｄ，加雷尼替丁胶囊１５０ｍｇ，ｂｉｄ；对照组（男性３７例，女性３例，年龄３８±１３ａ）单用雷尼替丁１５０ｍｇ，ｐｏ，ｂｉｄ。疗程均为４～６ｗｋ。结果：消化性溃疡治疗４ｗｋ和６ｗｋ的愈合率，治疗组是６２％和９６％，对照组是３０％和８５％，２组４ｗｋ和６ｗｋ的愈合率相比Ｐ＜０．０５和Ｐ＞０．０５。症状消失时间依次为８±３ｄ和１３±３ｄ，Ｐ＜０．０１。治疗后９～１２ｍｏ溃疡复发率依次为６％和１５％。结论：麦滋林－ｓ加雷尼替丁治疗消化性溃疡较单用雷尼替丁的效果好。
Objective: To observe the efficacy of mazolin-s plus ranitidine in the treatment of peptic ulcer. Methods: Eighty-seven cases of peptic ulcer diagnosed by gastroscope were randomly divided into treatment group (40 males and 7 females, age 38 ± s14a). Metronidazole-s0.67g, tid, plus ranitidine capsule 150mg, bid; control group (37 males and 3 females, age 38 ± 13a) ranitidine 150mg, po, bid. Treatment are 4 ~ 6wk. Results: The healing rates of peptic ulcer at 4wk and 6wk were 62% and 96% in treatment group and 30% and 85% in control group, respectively. The healing rates of 4wk and 6wk in 2 groups were significantly lower than those in P <0.05 and P> 0 .05. Symptoms disappear time followed by 8 ± 3d and 13 ± 3d, P <0.01. The recurrence rates of ulcer after 9 ~ 12 months were 6% and 15%, respectively. Conclusion: Mazolin-s plus ranitidine treatment of peptic ulcer with ranitidine alone better effect.