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目的:分析别嘌醇不良反应特点和相关因素,为规避临床用药风险提供参考。方法:对北京地区医疗机构近10年报告的107例别嘌醇的不良反应发生特点、规律和预后进行归纳、分析。结果:107例不良反应中严重不良反应27例(占25.23%),最常见的不良反应为皮肤-黏膜系统反应,共70例(占65.42%),其主要表现为皮疹、多形红斑、剥脱性皮炎等,其他不良反应包括肝肾功能异常及胃肠道反应等。结论:临床上使用该药要加强不良反应监测,尤其应注意日总剂量不要大于600 mg。
Objective: To analyze the characteristics and related factors of allopurinol adverse reactions, to provide a reference for avoiding the risk of clinical medication. Methods: The characteristics, regularity and prognosis of 107 cases of allopurinol reported by medical institutions in Beijing in recent 10 years were summarized and analyzed. Results: Of the 107 adverse reactions, 27 were serious adverse reactions (25.23%). The most common adverse reactions were skin-mucosal system reactions, with 70 cases (65.42%). The major adverse reactions were rash, erythema multiforme, Dermatitis and other adverse reactions, including liver and kidney dysfunction and gastrointestinal reactions. Conclusion: Clinical use of this drug should strengthen the monitoring of adverse reactions, with particular attention to the total daily dose of not more than 600 mg.