论文部分内容阅读
目的:建立以固相萃取反相高效液相色谱法测定人血浆中兰索拉唑浓度的方法。方法:避光条件下采用固相萃取法处理血7.6样),,流反速相为高1效.0液mL相·色mi谱n-法1,柱测温定为兰室索温拉,唑检血测药波浓长度为,2色84谱nm柱,为进样Ve量nu为sil2X0BμPL-。C结18,果流:动兰相索为拉乙唑腈血-药水浓(3度2在:681,0用～21%50氨0n水g·调mLpH-1值范围至内线性关系良好(r=0.9999);平均相对回收率为100.93%,日内、日间RSD<10%。结论:本方法灵敏、简便、快速,可用于血浆中兰索拉唑的测定。
Objective: To establish a method for the determination of lansoprazole in human plasma by solid-phase extraction reversed-phase high performance liquid chromatography. Methods: The sample was treated with solid-phase extraction under the dark conditions for blood 7.6), and the flow rate was 1-fold higher. , Azole test blood test wave length, 2-color 84 spectrum nm column, the amount of injected Ve nu is sil2X0BμPL-. C knot 18, the flow of fruit: moving blue phase cable for the pull azacin nitrile blood - strong syrup (3 degrees 2 at: 681,0 with ~ 21% 50 ammonia 0n water g · adjust mLpH-1 value range to within a good linear relationship (r = 0.9999). The average relative recovery was 100.93%, and the intra-day and inter-day RSD was less than 10% .Conclusion: The method is sensitive, simple and rapid and can be used for the determination of lansoprazole in plasma.