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目的分析降钙素原(PCT)检测在新生儿败血症早期诊断治疗和病情评估的临床价值。方法新生儿败血症36例,普通细菌感染的肺炎患儿38例为对照组,观察治疗初期和治疗后PCT、CRP和WBC计数值及其敏感度和特异度;分析败血症组PCT与SOFA评分和PCIS评分进行相关性。结果败血症组的PCT和CRP与对照组比较,差异有统计学意义(P<0.05)。PCT、CRP、WBC计数的灵敏度分别为96.67%、93.33%和86.67%;其特异度分别为83.33%、66.67%和33.33%,均高于CRP和WBC计数的敏感度和特异度。败血症组新生儿恢复期在PCT、CRP和WBC计数低于对照组(P<0.05),血清PCT水平与SOFA评分呈正相关,与PCIS评分呈负相关性。结论 PCT有利于新生儿败血症的早期诊断和病情观察,值得在临床上推广应用。
Objective To analyze the clinical value of procalcitonin (PCT) detection in the early diagnosis and treatment of neonatal sepsis and the evaluation of its condition. Methods Thirty-six neonates with septicemia and thirty-eight children with pneumonia were selected as the control group. The counts of PCT, CRP and WBC and the sensitivity and specificity of PCT, CRP and WBC were observed before and after treatment. The correlations of PCT, SOFA and PCIS Score for relevance. Results The difference of PCT and CRP between sepsis group and control group was statistically significant (P <0.05). The sensitivity of counting PCT, CRP and WBC were 96.67%, 93.33% and 86.67% respectively. The specificity of PCT, CRP and WBC were 83.33%, 66.67% and 33.33% respectively, which were higher than the sensitivity and specificity of CRP and WBC count. Serum PCT levels were positively correlated with SOFA score and negatively correlated with PCIS score in neonatal convalescent sepsis group when PCT, CRP and WBC count were lower than those in control group (P <0.05). Conclusion PCT is good for early diagnosis and observation of neonatal septicemia, which is worth popularizing in clinic.