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常规提取的黄芪多糖经液相色谱进一步分离后,发现其中分子量为20 000～25 000的组分,对正常人及肿瘤患者外周血单个核细胞(PBMC)在体外分泌肿瘤坏死因子(TNF)具有明显地促进作用。进一步将PBMC分离成粘附和非粘附细胞后发现,黄芪多糖的这一组分对二者分别产生TNF-α和TNF-β均有增强作用,表明对黄芪多糖的进一步研究将有利于其在肿瘤治疗中的应用。
The conventionally extracted astragalus polysaccharides were further separated by liquid chromatography and found that the components with a molecular weight of 20 000 to 25 000 had the ability to secrete tumor necrosis factor (TNF) in peripheral blood mononuclear cells (PBMC) from normal and tumor patients. Clearly promotes function. After further separating PBMCs into adherent and non-adherent cells, it was found that this component of Astragalus polysaccharides enhanced the production of TNF-α and TNF-β, respectively, indicating that further research on Astragalus polysaccharides would be beneficial to them. Application in cancer treatment.