西咪替丁治疗成人难治性疣比安慰剂有效吗?

• 作 者: 陈小红 陈志强
• 出 处: 国外医学.皮肤性病学分册
• 发表日期: 2000年06期
• 关键词: 西咪替丁 安慰剂 受体拮抗剂 相互作用 差异有显著性 最大疗效 寻常疣 免疫缺陷者 肾疾病患者 皮损数目

大剂量西咪替丁可作为免疫调节剂而增强细胞介导的免疫应答,它在治疗儿童和成人难治性疣中已显示有前景,但两项安慰剂对照研究未曾证实其疗效。该研究以严格的入选标准、采用安慰剂对照双盲法观察标准剂量西咪替丁对成人难治性疣的疗效。46例病程不少于2年的寻常疣患者纳入该研

High doses of cimetidine, which acts as an immunomodulator to enhance the cell-mediated immune response, has shown promise in the treatment of children and adult refractory warts, but two placebo-controlled studies have not confirmed its efficacy. The study used rigorous inclusion criteria to evaluate the efficacy of standard-dose cimetidine on adult refractory warts using a placebo-controlled double-blind trial. Forty-six patients with condyloma acuminatum who had a duration of at least 2 years were included in the study