论文部分内容阅读
目的:探讨妊娠期糖尿病孕妇外周血及胎盘组织NF-κB表达与胰岛素抵抗的相关性。方法:选择孕中晚期糖尿病孕妇120例为观察组,正常孕妇60例为对照组,对两组空腹血糖(FPG)、胰岛素(FINs)、胰岛素抵抗指数(HOMAIR)、核因子-κB(NF-κB)活性以及E-选择素(sE-let)和可溶性细胞间粘附分子-1(sICAM-1)水平进行观察和比较。结果:与对照组相比,观察组FPG、FINs、HOMA-IR均明显升高,sE-let、sICAM-1及NF-κB水平均明显升高,差异均有统计学意义(P<0.05),并且NF-κB活性与sE-let、sICAM-1、FINs及HOMA-IR水平呈正相关性。结论:妊娠期糖尿病患者外周血NF-κB活性明显升高,可能通过上调sE-let和sICAM-1表达参与胰岛素抵抗的发生、发展。
Objective: To investigate the relationship between the expression of NF-κB in peripheral blood and placenta of pregnant women with gestational diabetes mellitus and insulin resistance. Methods: One hundred and twenty pregnant women with middle-late stage of pregnancy were selected as observation group and 60 normal pregnant women as control group. FPG, Hs-IR, κB) activity and the levels of sE-let and sICAM-1 were observed and compared. Results: Compared with the control group, the levels of FPG, FINs and HOMA-IR in the observation group were significantly increased, the levels of sE-let, sICAM-1 and NF-κB were significantly increased (P <0.05) , And NF-κB activity was positively correlated with sE-let, sICAM-1, FINs and HOMA-IR levels. Conclusion: The activity of NF-κB in peripheral blood of patients with gestational diabetes mellitus is obviously increased, which may be involved in the development of insulin resistance by up-regulating sE-let and sICAM-1 expression.