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目的：观察 Ｃ Ｅ Ａ 及 Ｐ５３ 蛋白在１６２ 例卵巢粘液性肿瘤中表达状况。方法：应用免疫组化方法检测６２ 例良性肿瘤，５８ 例临界性腺瘤，４２ 例恶性肿瘤中 Ｃ Ｅ Ａ 及 Ｐ５３ 蛋白的表达。结果：６２ 例良性肿瘤中， Ｃ Ｅ Ａ 阳性者６ 例（９ ．６８ ％ ） ， Ｐ５３ 全部阴性；５８ 例临界性腺瘤中， Ｃ Ｅ Ａ 阳性者５４ 例（９３ ．１ ％ ） ， Ｐ５３ 阳性者１０ 例（１７ ．２４ ％ ） ；４２ 例恶性肿瘤中， Ｃ Ｅ Ａ 阳性者４０ 例（９５ ．２３ ％ ） ， Ｐ５３ 阳性者２３例（５４ ．７６ ％ ） 。分别与良性肿瘤间经χ２ 检验，除临界性肿瘤 Ｐ５３ 阳性标记 Ｐ＜ ０ ．０２５ 外，余均 Ｐ＜ ０ ．０１ ，差异非常显著。结论：部分临界性肿瘤应属恶性，且 Ｃ Ｅ Ａ 阳性标记者易发生种植及转移。在卵巢粘液性肿瘤由良性向恶性转化过程中， Ｐ５３ 蛋白的表达，提示了 Ｐ５３ 基因突变参与了这一转化过程。
Objective: To observe the expression of C E A and P53 protein in 162 cases of ovarian mucinous tumors. Methods: The expressions of C E A and P53 in 62 cases of benign tumor, 58 cases of critical adenoma and 42 cases of malignant tumor were detected by immunohistochemistry. Results: In 62 cases of benign tumors, 6 cases (9.68%) of C E A positive and P53 were all negative. Among 58 cases of critical adenomas, 54 cases (93.1%) of C E A positive were positive for P53 Among the 42 malignant tumors, 40 (95.23%) had C E A positive and 23 (54.76%) had P53 positive. Respectively with the benign tumor by χ2 test, except for the P53-positive tumor markers P <0. 025, the remaining P <0. 01, the difference is very significant. Conclusion: Some of the borderline tumors should be malignant, and C E A positive markers are easy to grow and metastasize. In the process of benign to malignant transformation of ovarian mucinous tumors, the expression of P53 protein suggests that P53 gene mutation is involved in this transformation process.