一种新的肿瘤转移抑制基因TMSG—l的研究现状(英文)

• 作 者: 徐晓艳 裴斐 由江峰
• 机 构: Peking University Health Science Center Department of Pathology,School of Basic Medical Sciences,
• 出 处: 癌症
• 发表日期: 2010年07期
• 关键词: TMSG metastasis invasion suppressor inhibiting metastatic ATPase encoded inhibit

TMSG-1 is a newly discovered tumor metastasis suppressor gene,which plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells.The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H+-ATPase and ceramide,but the underlying mechanism remains unknown.Studies on TMSG-1 are limited worldwide,and only a research group in Shanghai and our group have recently studied on it.As a new research field,the function of TMSG-1 remains to be explored.This review discusses the discovery of TMSG-1,structure of its encoded protein,its roles and possible mechanism in inhibiting tumor invasion and metastasis.

TMSG-1 is a newly discovered tumor metastasis suppressor gene, which plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells. The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H + -ATPase and ceramide, but the underlying mechanism remains unknown. Situations on TMSG-1 are limited worldwide, and only a research group in Shanghai and our group have recently studied on it. As a new research field, the function of TMSG-1 remains to be explored. This review discusses the discovery of TMSG-1, structure of its encoded protein, its roles and possible mechanism in inhibiting tumor invasion and metastasis.