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本文报导34例溃疡病人服用甲氰咪胍后胃内环境的变化以及甲氰咪胍和维生素C同服对胃内环境、特别是对亚硝酸盐含量的影响。结果显示:服甲氰咪胍后,胃液pH值、亚硝酸盐及细菌总数明显增加(P<0.01);而甲氰咪胍和维生素C同时服用,亚硝酸盐无明显增加(P>0.05),且两个治疗组的BAO、PAO和MAO无明显差异。说明在服用甲氰咪胍时,同时服用维生素C可以防止由于甲氰咪胍引起的亚硝酸盐含量增高的现象,而对甲氰咪胍的抑酸作用无明显影响,这对甲氰咪胍及其它强抑酸剂可能具有重要的意义。
This article reports 34 cases of gastric ulcer patients taking cimetidine changes in the gastric environment and cimetidine and vitamin C with the stomach on the environment, especially on the nitrite content. The results showed that pH value, nitrite and total bacteria in gastric juice increased significantly (P <0.01) after taking cimetidine, while nitrite did not increase significantly (P> 0.05) , And there was no significant difference between BAO, PAO and MAO in the two treatment groups. Description of taking cimetidine, taking vitamin C at the same time can be prevented due to cimetidine caused by the phenomenon of increased nitrite, and the inhibition of cimetidine no significant effect, which cimetidine And other strong acid suppression agents may have important significance.