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目的 :观察虫草制剂金水宝对维持性血液透析 (MHD)患者外周血T细胞凋亡和FasL表达的影响。方法 :应用流式细胞仪 (FCM)定量检测了 30名MHD患者 (血透组 )、30名MHD加金水宝治疗 3个月患者 (中药组 )的外周血T细胞在体外无刺激培养 2 4h后AnnexinⅤ和FasL的表达。结果 :血透组T细胞AnnexinⅤ和FasL表达显著高于中药组 (P <0 .0 5 ) ,两组AnnexinⅤ和FasL之间呈显著正相关 (P <0 .0 5 ) ,而AnnexinⅤ与Ccr间呈显著负相关 (P <0 .0 5 )。结论 :金水宝可显著减轻MHD患者的T细胞凋亡
Objective : To observe the effect of Cordyceps militaris Jinshuibao on peripheral blood T cell apoptosis and FasL expression in maintenance hemodialysis (MHD) patients. METHODS: Quantitative detection of peripheral blood T cells from 30 patients with MHD (hemodilysis group) and 30 patients with MHD plus Jinshuibao for 3 months (Chinese medicine group) was quantified by flow cytometry (FCM) in vitro without stimulation for 24 hours. Expression of AnnexinV and FasL. Results: The expression of AnnexinV and FasL in T cells of hemodialysis group was significantly higher than that in TCM group (P < 0.05). There was a significant positive correlation between AnnexinV and FasL in both groups (P < 0.05), and between AnnexinV and Ccr. There was a significant negative correlation (P < 0.05). Conclusion : Jinshuibao can significantly reduce T cell apoptosis in patients with MHD