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目的 调查和探讨长期使用抗精神病药患者血瘦素水平及其与服用抗精神病药后体重 增加、肥胖及糖尿病之间的关系。方法 对符合入组标准的308例长期服用抗精神病药的精神分裂症 患者分为对照组、肥胖组、糖耐量减低组及糖尿病组,比较血清瘦素水平、胰岛素抵抗指数、血清甘油三 酯及总胆固醇水平。结果 (1)肥胖组、糖耐量减低组及糖尿病组患者的血清瘦素水平、胰岛素抵抗指 数、血清甘油三酯及总胆固醇水平均显著高于对照组(P<0.05)。(2)长期应用抗精神病药患者血瘦 素水平与体重指数、简易胰岛素抵抗指数、空腹血糖、血甘油三酯及胆固醇均呈极显著正相关(P<0.01 ～0.0001),而与餐后2h血糖水平及用药时间无相关性。结论 长期应用抗精神病药患者血瘦素水 平在肥胖、糖耐量降低及糖尿病患者中显著升高,且与体重指数、简易胰岛素抵抗指数、空腹血糖水平等 均呈显著正相关,提示高血清瘦素水平是长期应用抗精神病药所致的代谢紊乱综合征的重要指征之一。
Objective To investigate and explore the level of serum leptin in long-term use of antipsychotics and its relationship with weight gain, obesity and diabetes after taking antipsychotics. Methods A total of 308 schizophrenic patients taking long-term antipsychotics who met the inclusion criteria were divided into control group, obesity group, impaired glucose tolerance group and diabetic group. Serum leptin level, insulin resistance index, serum triglyceride Total cholesterol level. Results (1) Serum leptin level, insulin resistance index, serum triglyceride level and total cholesterol level in obesity group, impaired glucose tolerance group and diabetic group were significantly higher than those in control group (P <0.05). (2) Serum leptin levels were significantly and positively correlated with body mass index, simple insulin resistance index, fasting blood glucose, triglycerides and cholesterol (P <0.01 ~ 0.0001), but not with 2h No correlation between blood glucose level and medication duration. CONCLUSIONS: Serum leptin levels are significantly elevated in obese, impaired glucose tolerance and diabetes mellitus patients with long-term use of antipsychotics, and positively correlated with body mass index, simple insulin resistance index and fasting blood glucose level, suggesting that serum leptin Level is long-term use of antipsychotic metabolic syndrome caused by one of the important indications.