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目的探讨食管鳞癌组织中复制蛋白A(RPA)的表达及临床意义。方法收集食管癌根治手术切除标本40例,病理均为鳞状细胞癌。用免疫组织化学法检测食管癌组织及癌旁正常组织中RPA1和RPA2的表达。结果食管癌组织RPA1表达阳性率为65.25%,明显高于癌旁正常组织的35.65%(P<0.01);癌组织RPA2表达阳性率58.90%,亦明显高于癌旁组织的16.71%(P<0.01)。结论 食管癌组织中RPA1、RPA2的表达明显高于同一标本的癌旁正常组织。RPA1、RPA2可能在食管癌的发生、发展过程中起一定的作用。
Objective To investigate the expression of replicon protein A (RPA) in esophageal squamous cell carcinoma and its clinical significance. Methods Forty cases of resected esophageal cancer specimens were collected. The pathology was squamous cell carcinoma. The expression of RPA1 and RPA2 in esophageal cancer tissues and adjacent normal tissues was detected by immunohistochemistry. Results The positive rate of RPA1 expression in esophageal cancer tissues was 65.25%, which was significantly higher than that in adjacent normal tissues (35.65%, P <0.01). The positive rate of RPA2 expression in esophageal cancer tissues was 58.90%, significantly higher than that in adjacent tissues (16.71%, P < 0.01). Conclusion The expression of RPA1 and RPA2 in esophageal carcinoma was significantly higher than that in normal tissues adjacent to the same specimen. RPA1, RPA2 may play an important role in the occurrence and development of esophageal cancer.