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目的:通过检测新生儿缺血缺氧性脑病(HIE)患儿中超敏C-反应蛋白(h-CRP)的变化,探讨其在HIE诊断中的作用。方法:选择46例HIE患儿为HIE组,选择同期正常足月新生儿21例为对照组,分别留取48h内血清标本,并检测两组h-CRP浓度。结果:正常组与HIE组血清h-CRP浓度分别为(0.17±0.12)mg/dl与(1.74±0.67)mg/dl,两组比较,有显著性差异(t=2.631,P<0.05);轻度HIE组与中重度HIE组血清h-CRP浓度分别为(0.62±0.53)mg/dl与(2.11±0.82)mg/dl,两组比较,有非常显著性差异(t=2.316,P<0.01)。结论:血清h-CRP浓度作为生化指标,可提示HIE的发生,并能反映其严重程度。
Objective: To explore the role of H-CRP in the diagnosis of HIE by detecting the changes of h-CRP in neonates with hypoxic-ischemic encephalopathy (HIE). Methods: Forty-six children with HIE were selected as HIE group. 21 normal newborn infants were selected as the control group. The serum samples were collected within 48 hours and the concentrations of h-CRP were measured. Results: The serum concentrations of h-CRP in normal group and HIE group were (0.17 ± 0.12) mg / dl and (1.74 ± 0.67) mg / dl, respectively. There was significant difference between the two groups (t = 2.631, P <0.05). The serum h-CRP levels in mild HIE group and moderate-severe HIE group were (0.62 ± 0.53) mg / dl and (2.11 ± 0.82) mg / dl respectively, with significant difference between the two groups (t = 2.316, 0.01). Conclusion: Serum h-CRP concentration as a biochemical indicator of HIE can prompt the occurrence, and can reflect the severity.