Effect of partial depletion of CD25+ T cells on neurological deficit and tissue damage in acute cere

• 作 者: Ana L Rodríguez-Perea Joh
• 机 构: GrupoInmunovirologia,Bacterias&,Cá,ncer,FacultaddeCienciasdelaSalud,GrupodeInmunologí,aCe
• 出 处: 急性病杂志(英文版)
• 发表日期: 2018年6期
• 关键词: TRANSITORY middle cerebral artery OCCLUSION Rat Anti-CD25 REGULATORY T cells ISC
• 基金项目: Universidad de Antioquia UdeA(Sostenibilidad and CODI Acta 624 de 2012),COLCIENCIAS(Grant 111551928730).

Objective: To evaluate the role of regulatory T cells (Tregs) at late stages of stroke. Methods:Anti-CD25 antibody (or PBS as a control) was injected to reduce the pool of Tregs in Wistar rats;then, ischemia was induced transiently by middle cerebral arte