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以往关于雌鼠年龄是否影响卵母细胞辐射遗传敏感性的研究很多,但其结果很不一致.许多研究提示老龄雌鼠生殖细胞的辐射敏感性高于幼龄鼠,而另有一些实验结果表明两个年龄组的辐射敏感性无差异,即使排除了实验变量的影响(如辐射剂量、卵母细胞所处阶段及细胞遗传学终点等),其实验结果仍是矛盾的.为进一步证明雌鼠年龄对辐射敏感性的影响,进行了两批实验.实验动物采用10～12和48～55周龄的C3H/HeH×101/H的F_1雌鼠,尾侧X射线半身照射.实验一的两个年龄组各设2个照射剂量点,照射剂量分别为2和4Gy(250kV,0.734Gy/分),照后16.5天用
In the past, there were many studies on whether female mice age affected the genetic sensitivity of oocyte radiation, but the results were very different.Many studies suggested that the radiation sensitivity of germ cells of old female mice was higher than that of young mice, while some other experimental results showed that two There was no difference in the radiosensitivity of age groups, and the experimental results were still contradictory even though the influence of experimental variables (such as radiation dose, stage of oocyte and end of cytogenetics, etc.) was excluded.In order to further prove that female mice age Two groups of experiments were conducted on the effects of radiosensitivity.Experimental animals were subjected to X-ray half-body irradiation with C3H / HeH × 101 / H for 10-12 and 48-55 weeks old Two irradiation dose points were set in each age group. The irradiation doses were 2 and 4 Gy (250 kV, 0.734 Gy / min), respectively, and 16.5 days after irradiation