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目的探析凝血功能指标检测对于手术患者的临床意义。方法选取111例大手术患者作为观察组,另选同时期101例健康体检者作为对照组。在术前及术后第1天、第3天、第5天对两组研究对象进行抽血检测,包括凝血酶原时间、凝血活酶时间、纤维蛋白、血管性血友病因子及D-二聚体等,检测其数值变化。结果两组凝血酶原时间及凝血活酶时间比较,差异无统计学意义(P>0.05)。观察组患者术后第1天纤维蛋白、血管性血友病因子及D-二聚体分别为(5.2±0.4)g/L、(220.1±20.4)、(0.8±0.2)μg/L,术后第3天的分别为(4.3±0.3)g/L、(122.8±14.7)、(0.6±0.1)μg/L,明显高于对照组的(2.5±0.5)g/L、(93.1±12.6)、(0.4±0.1)μg/L(P<0.05)。观察组患者术后第5天各项凝血功能指标与对照组比较差异无统计学意义(P>0.05)。结论通过展开常规凝血功能检测,可帮助手术患者安全度过术后血液高凝时期,对于潜在的血栓及栓塞做到及时的预防治疗,因而具有极高的临床应用与推广价值。
Objective To investigate the clinical significance of coagulation test in surgical patients. Methods 111 cases of major surgery patients were selected as the observation group, while 101 healthy subjects were selected as the control group. Preoperative and postoperative 1 day, 3 days, 5 days on the two groups of subjects blood tests, including prothrombin time, thromboplastin time, fibrin, von willebrand factor and D- Dimers, etc., to detect changes in its value. Results There was no significant difference in prothrombin time and thromboplastin time between the two groups (P> 0.05). The fibrin, vWF and D-dimer in the observation group were (5.2 ± 0.4) g / L, (220.1 ± 20.4) and (0.8 ± 0.2) μg / L (4.3 ± 0.3) g / L, (122.8 ± 14.7) and (0.6 ± 0.1) μg / L on the third day after operation were significantly higher than those in the control group (2.5 ± 0.5) g / L and (93.1 ± 12.6 ), (0.4 ± 0.1) μg / L (P <0.05). There was no significant difference between the observation group and the control group on the fifth day after operation (P> 0.05). Conclusion By carrying out routine coagulation tests, it can help patients surgically survive the postoperative hypercoagulable stage of blood clotting and provide timely prevention and treatment for potential thrombosis and embolism. Therefore, it is of great clinical application and promotion value.