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目的 研究 p5 3蛋白对外阴白斑和鳞癌细胞中的表达 .方法 采用 ABC免疫组化法 ,对 10 2例外阴白斑和鳞癌患者进行 p5 3蛋白检测 .结果 各组与鳞癌组相比 ,经 χ2检验 ,有非常显著差别 (P<0 .0 1) .正常组 2 1例 χ2 =2 4.0 2 ,增生组 2 0例χ2 =9.2 3,硬化萎缩组 2 8例χ2 =5 3.2 3,混合组 2 3例 χ2 =138.39,不典型增生组 8例 χ2 =13.5 3.结论 p5 3蛋白的表达与鳞癌有密切关系 ,为肿瘤的恶性标志 ,说明 p5 3蛋白检测可作为良恶性病变之间的鉴别手段
Objective To study the expression of p53 protein in leukoplakia and squamous cell carcinoma. Methods ABC immunohistochemistry was used to detect p53 protein in 102 patients with leukoplakia and squamous cell carcinoma. Results Compared with squamous cell carcinoma group, After the χ2 test, there was a very significant difference (P<0.01). In the normal group, there were 21 cases with χ2 = 2 4.02, the proliferative group with 20 cases with χ2 = 9.23, and the hardened and atrophied group with 28 cases with χ2 = 53.23. In the mixed group, 23 cases of χ2 = 138.39, and 8 cases of atypical hyperplasia χ2 = 13.5. 3. Conclusions The expression of p53 protein is closely related to squamous cell carcinoma. It is a malignant marker of tumor, indicating that the detection of p53 protein can be used as benign and malignant lesions. Interrogative means