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目的:观察神经生长因子对慢性酒精中毒周围神经病的疗效。方法:68例慢性酒精中毒周围神经病的患者随机分为NGF组36例和对照组32例,以治疗前后临床症状和神经电生理为观察指标。结果:NGF组临床有效率达94.4%,对照组的有效率为68.8%(P<0.01)。NGF组患者的感觉、运动传导速度同治疗前相比显著提高(P<0.01),同对照组相比差异也有显著性(P<0.01,P<0.05)。结论:神经生长因子对慢性酒精中毒周围神经病疗效显著,神经传导速度可以作为判断疗效的一个指标。
Objective: To observe the effect of nerve growth factor on peripheral neuropathy of chronic alcoholism. Methods: Sixty-eight patients with peripheral neuropathy of chronic alcoholism were randomly divided into NGF group (n = 36) and control group (n = 32). The clinical symptoms and neuroelectrophysiology were observed before and after treatment. Results: The clinical effective rate was 94.4% in NGF group and 68.8% in control group (P <0.01). The sensory and motor conduction velocity in NGF group were significantly higher than those before treatment (P <0.01), and also significantly different from those in control group (P <0.01, P <0.05). Conclusion: The effect of NGF on peripheral neuropathy in patients with chronic alcoholism is significant. Nerve conduction velocity can be used as an indicator to evaluate curative effect.