Secondary metabolites and their biological activities in Indonesian soft coral of the genus Lobophyt

• 作 者: Masteria Yunovilsa Putra Tutik Murniasih Respati Tri Swasono Joko Tri Wibowo Annissa Nur Cahya Saputri Meilia Rahma Widhiana Irma Shita Arlyza
• 机 构: Research Center for Oceanography, Indonesian Institute of Sciences, Jl.Pasir Putih I,Department of C
• 出 处: Asian Pacific Journal of Tropical Biomedicine
• 发表日期: 2016年11期
• 关键词: polymerization antibacterial picryl crude Secondary scavenging shrimp antioxidan

Objective: To investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of the n-hexane, ethyl acetate, n-butanol, and aqueous fractions from a crude extract of Lobophytum sp.Methods: This organism was collected from the Selayar Islands(South Sulawesi). The antioxidant activity was performed by the 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All fractions from the crude extract of Lobophytum sp. were examined for their cytotoxicity using the brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antimalarial activity.Results: It was found that the ethyl acetate, n-butanol and aqueous fractions exhibited heme polymerization inhibitory activity with IC_(50) values of 11.7, 14.3 and 12.0 mg/m L,respectively, while the n-butanol fraction showed moderate antioxidant activity and cytotoxicity with IC_(50) values of 150.00 and 92.74 mg/m L, respectively.Conclusions: This study provides information on antioxidant, antibacterial and antimalarial activities as well as the cytotoxicity of all fractions from the crude extract of Lobophytum sp. This is a new report of antimalarial substances derived from Lobophytum sp.

Objective: To investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of the n-hexane, ethyl acetate, n-butanol, and aqueous fractions from a crude extract of Lobophytum sp. Methods: This organism was collected from the Selayar Islands (South Sulawesi ) The antioxidant activity was performed by the 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All fractions from the crude extract of Lobophytum sp. Were examined for their cytotoxicity using the brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antimalarial activity. Results: It was found that the ethyl acetate, n-butanol and aqueous fractions showed heme polymerization inhibitory activity with IC 50 values ​​of 11.7, 14.3 and 12.0 mg / m L, respectively, while the n-butanol fraction had moderate antioxidant activity and cytotoxicity with IC 50 values ​​of 150.00 and 92.74 mg / m L, respectively. Conclusions: This study provides information on antioxidant, antibact This is a new report of antimalarial substances derived from Lobophytum sp.