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妊娠期高血压综合征(pregnancy-induced hypertension syndrome,PIH)多发生于妊娠20周以后,是以高血压、蛋白尿、水肿为特征的多脏器功能受损的临床综合征,发病率高达6%~8%[1]。传统治疗方法首选硫酸镁,但其存在某些病例疗效不佳和药物中毒的危险,造成其对妊高征的治疗有一定的缺憾性。近年来发现川芎嗪对妊高征的治疗有显著的疗效,但较多研究均为小样本,且质量不一,其确切疗效缺乏多中心、大样本临床试验的有力支持。本文采用Meta分析方法对国内外近20年来公开发表的有关川芎嗪治疗PIH的文献进行综合定量分析,以
Pregnancy-induced hypertension (PIH) occurs mostly after 20 weeks of pregnancy and is a clinical syndrome characterized by hypertension, proteinuria and edema, with a morbidity of up to 6 % ~ 8% [1]. Traditional methods of treatment preferred magnesium sulfate, but there are some cases of poor efficacy and the risk of drug poisoning, resulting in its treatment of pregnancy-induced hypertension has some shortcomings. In recent years, it has been found that ligustrazine has a significant effect on the treatment of PIH. However, most of the studies are small samples with different qualities. The exact curative effect lacks the support of multi-center and large sample clinical trials. In this paper, a comprehensive quantitative analysis of the literatures about ligustrazine treatment of PIH published in the past 20 years both at home and abroad by Meta analysis method