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白癜风是一种常见的色素脱失性疾病，与其他自身免疫性疾病密切相关。目前，白癜风的发病机制存在多种假说，学者认为细胞及体液免疫共同介导的黑素细胞破坏是白癜风发病的主要原因。白癜风患者外周血和皮肤活检提示，淋巴细胞、单核细胞、炎性介质及自身抗体等均参与了黑素细胞的破坏，但自身免疫是否是白癜风的主要发病机制，亦或只是一个参与者，仍需要进行深入探索。“,”Vitiligo is a common depigmenting disorder which is closely associated with autoimmune dis-orders.Various hypotheses have been proposed to explain the pathomechanisms involved in this disease . Scholars believe that the cell and humoral autoimmune mediated melanocytes destruction is the most accredi-ted mechanism of vitiligo.Peripheral blood and skin biopsies of patients with vitiligo show that lymphocytes , mononuclear cells,various inflammatory cytokines and auto-antibodies are all involved in the damage of mela-nocytes.Further research is currently under way to figure out whether autoimmunity is the main mechanism of vitiligo or only a consequence .