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目的探讨在卵巢低反应体外受精治疗周期中GnRH拮抗剂与激动剂短方案临床应用比较。方法研究对象为符合卵巢低反应的患者80例,共80个周期。随机分为两组:GnRH拮抗剂组及GnRH激动剂短方案组,分别为40个周期。将两组患者的年龄、不孕年限、不孕原因、基础卵泡刺激素(FSH)水平、周期取消率、平均Gn使用时间、剂量、临床妊娠率、胚胎种植率等进行比较。结果两组患者病因、年龄、不孕年限、基础FSH比较,差异均无统计学意义(P>0.05)。拮抗剂平均Gn使用天数、获卵数、移植胚胎数与激动剂比较差异无统计学意义(P>0.05)。拮抗剂平均Gn使用量、临床妊娠率、胚胎种植率与激动剂比较差异有统计学意义(P<0.05)。结论 GnRH拮抗剂对卵巢低反应患者是一种有效的超排卵治疗方案,可以减少费用,提高临床妊娠率。
Objective To investigate the clinical application of short GnRH antagonist and agonist in ovarian hypo-responsive IVF treatment cycles. Methods The object of study was 80 patients with low ovarian response, a total of 80 cycles. Randomly divided into two groups: GnRH antagonist group and GnRH agonist short-term group, respectively, 40 cycles. The age, duration of infertility, causes of infertility, basal follicle stimulating hormone (FSH) level, cycle cancellation rate, average Gn use time, dosage, clinical pregnancy rate and embryo implantation rate were compared between the two groups. Results There was no significant difference in etiology, age, duration of infertility and basic FSH between the two groups (P> 0.05). There was no significant difference in mean number of days of Gn use, number of oocytes retrieved, number of embryos transferred and agonists (P> 0.05). The average amount of antagonist Gn usage, clinical pregnancy rate, embryo implantation rate and the difference was statistically significant (P <0.05). Conclusion GnRH antagonist is an effective treatment for patients with low ovarian response to ovarian hyperstimulation, which can reduce the cost and improve the clinical pregnancy rate.