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采用给无菌大鼠管饲O_(111)B_4型埃氏大肠杆菌的方法,用抗O_(111)B_4型抗血清PAP技术在石蜡切片上定位显示了肠粘膜和其它脏器中该细菌的踪迹。发现了阳性染色颗粒(可能为细菌碎片和内毒素)和杆菌侵入肠粘膜基底部的病变并广泛分布于肠系膜淋巴结,肝、脾以及肺脏的血管内皮细胞和吞噬细胞中。该观察结果提示大量细菌和毒素可经肠粘膜深部病变进入血循环,它们在全身的播散与吞噬细胞功能有关。
Using a method of administering O_ (111) B_4 type Escherichia coli to aseptic rats, the anti-O_ (111) B_4 antiserum PAP technique was used to locate the bacteria in the gut mucosa and other organs trace. Positive staining particles (which may be bacterial debris and endotoxins) and bacilli were found to have lesions in the basement of the intestinal mucosa and were widely distributed in mesenteric lymph nodes, liver, spleen, and lung vascular endothelial cells and phagocytes. This observation suggests that a large number of bacteria and toxins may enter the bloodstream through the deep intestinal lesions and their spread throughout the body is related to phagocyte function.