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ABSTRCAT Objective: The effect of prevention and treatment of Xinkang oral liquid (心康口服液, XKOL) on experimental coxsackievirus B 3 (CVB 3) myocarditis mice model were investigated. Methods: The mice were inoculated intraperitoneally with 0.3 ml of 10 5 TCID 50 of CVB 3 to induce acute viral myocarditis model. These mice were divided into model control group (Group A), prevention high dosage group (Group B) and prevention low dosage group (Group C), treatment high dosage group (Group D) and treatment low dosage group (Group E), respectively. In addition, XKOL control group (Group F) and normal control group (Group G) were not infected with CVB 3 intraperitoneally. The administration of XKOL in Group B and C began 2 days before virus infection. All animals were sacrificed on day 20 for evaluation. Results: Histological examination showed extensive myocardial necrosis and cell infiltration in most of Group A mice, but necrosis and cell infiltration were less severe in Group B,C,D and E mice. Thymus weight in Group B,C,D and E mice were heavier and less cell depletion occurred than those in Group A. Conclussion: The XKOL could effectively inhibit myocardial CVB 3 replication, reduce the myocardial inflammatory response, lower incidence rate of myocarditis and prevent the disease associated lymphoid organ atrophy in this animal models.
ABSTRCAT Objective: The effect of prevention and treatment of Xinkang oral liquid (XKOL) on experimental coxsackievirus B 3 (CVB 3) myocarditis mice model were investigated. Methods: The mice were inoculated intraperitoneally with 0.3 ml of 10 5 TCID 50 of CVB 3 to induce acute viral myocarditis model. These mice were divided into model control group (Group A), prevention high dosage group (Group B) and prevention low dosage group (Group C), treatment high dosage group (Group D) And treatment low dosage group (Group E), respectively. In addition, XKOL control group (Group F) and normal control group (Group G) were not infected with CVB 3 intraperitoneally. The administration of XKOL in Group B and C began 2 days Before virus infection. All animals were sacrificed on day 20 for evaluation. Results: Histological examination showed minimal myocardial necrosis and cell infiltration in most of Group A mice, but necrosis and cell infiltration were less severe In Group B, C, D and E mice. Thymus weight in Group B, C, D and E mice were heavier and less cell depletion occurred than those in Group A. Conclussion: The XKOL could effectively inhibit myocardial CVB 3 replication, reduce the Myocardial inflammatory response, lower incidence rate of myocarditis and prevent the disease associated lymphoid organ atrophy in this animal models.