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恶性疟原虫在人体内的红内期和肝期寄生于富含氧的环境。宿主免疫系统、疟原虫自身代谢(如消耗红细胞中的血红蛋白)以及某些抗疟药的使用而产生的活性氧族(ROS)使疟原虫受到毒性作用。超氧化物歧化酶(SOD))、谷胱甘肽过氧化物酶(GPx)、过氧化氢酶是三种主要的抗活性氧酶。在恶性疟原虫中内源性SOD、GPx已得到鉴定,但内源性过氧化氢酶的存在尚无明确的报道。
Plasmodium falciparum parasites in an oxygen-rich environment during the red-phase and the liver-phase in humans. The host immune system, reactive oxygen species (ROS) produced by the parasite’s own metabolism (such as the consumption of hemoglobin in red blood cells), and the use of certain anti-malarial drugs, cause toxicity to the parasite. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase are the three major anti-active oxygenases. Endogenous SOD, GPx has been identified in Plasmodium falciparum, but the presence of endogenous catalase has not been clearly reported.