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目的探讨转录因子Dermo-1在涎腺腺样囊性癌中的表达水平及其与各临床病理因素的关系。方法采用免疫组化方法检测40例涎腺腺样囊性癌组织中Dermo-1蛋白的表达情况,分析Dermo-1表达与腺样囊性癌临床病理因素的关系,以20例正常涎腺组织作对照。结果 Dermo-1在涎腺腺样囊性癌组织中的表达水平明显高于正常涎腺组织(P<0.05)。Dermo-1表达与腺样囊性癌的病理分型、嗜神经侵袭、术后复发及远位转移有关(P<0.05)。结论 Dermo-1蛋白表达可能与涎腺腺样囊性癌的分化调节、嗜神经侵袭及远位转移有关系,检测Dermo-1的表达水平对判断腺样囊性癌患者的预后有一定的参考价值。
Objective To investigate the expression of Dermo-1 in salivary adenoid cystic carcinoma and its relationship with clinicopathological factors. Methods The expression of Dermo-1 protein in 40 cases of salivary adenoid cystic carcinoma was detected by immunohistochemistry. The relationship between the expression of Dermo-1 and clinicopathological parameters of adenoid cystic carcinoma was analyzed. Twenty normal salivary gland tissues As a control. Results The expression of Dermo-1 in salivary adenoid cystic carcinoma was significantly higher than that in normal salivary gland (P <0.05). The expression of Dermo-1 was related to pathological type, invasion of esophageal nerve, recurrence and distant metastasis of adenoid cystic carcinoma (P <0.05). Conclusions The expression of Dermo-1 may be related to the differentiation regulation of salivary adenoid cystic carcinoma, the invasion of esophageal nerve and distant metastasis. The detection of the expression level of Dermo-1 may be useful for judging the prognosis of patients with adenoid cystic carcinoma value.