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目的：为了解在慢性阻塞性肺病（ＣＯＰＤ）中尘螨过敏的发生状况，以及尘螨过敏对急性加重发生的作用。方法：采用常用的过敏参数和检测手段，对１４９例住院的ＣＯＰＤ、支气管哮喘和非呼吸系统疾病的患者进行分组检测，其中ＣＯＰＤ５９例，支气管哮喘３０例，非呼吸系统疾病患者６０例。测定痰找嗜酸细胞（ＥＯＳ）、外周血嗜酸细胞计数、血清ＩｇＥ和屋尘螨（ＨＤＭ）皮肤过敏试验。同时进行居住条件、不良卫生习惯和软家具设施调查。结果：与非呼吸系统疾病患者相比，ＣＯＰＤ患者痰找ＥＯＳ增加，外周血ＥＯＳ计数增加，血清ＩｇＥ增高和皮肤试验阳性率均有显著差异；而与支气管哮喘组相比，痰找ＥＯＳ及皮肤试验阳性率无差异（Ｐ＞００５），虽ＣＯＰＤ组外周血ＥＯＳ计数和ＩｇＥ浓度有增高比支气管哮喘者仍有差异（Ｐ＜０．０１）。ＣＯＰＤ皮试阳性组较阴性组两年内急性加重次数明显增多。结论：ＣＯＰＤ患者存在着ＨＤＭ暴露与过敏，ＨＤＭ过敏对于ＣＯＰＤ患者急性加重的作用应值得重视；ＣＯＰＤ患者ＨＤＭ过敏的原因可能与居住条件不良和卫生习惯不良有关
Objective: To understand the occurrence of dust mite allergy in chronic obstructive pulmonary disease (COPD) and the role of dust mite allergy in acute exacerbations. Methods: A total of 149 inpatients with COPD, bronchial asthma and non-respiratory diseases were divided into groups by commonly used allergy parameters and testing methods. Among them, 59 were COPD, 30 were bronchial asthma and 60 were non-respiratory diseases. Phlegm finding eosinophils (EOS), peripheral blood eosinophil counts, serum IgE and house dust mite (HDM) skin allergy tests. At the same time living conditions, poor health habits and soft furniture facilities survey. Results: Compared with patients with non-respiratory diseases, patients with COPD had higher EOS, increased counts of EOS in peripheral blood, increased serum IgE and positive rates of skin test. Compared with bronchial asthma group, sputum showed EOS and skin There was no difference between the two groups (P> 005). Although the EOS count and IgE concentration in COPD group were still higher than those in bronchial asthma group (P <0.01). COPD skin test positive group than in the negative group within two years significantly increased the number of acute exacerbation. Conclusions: HDM exposure and allergy exist in patients with COPD. HDM allergy should be emphasized in patients with acute exacerbation of COPD. The causes of HDM allergy in COPD patients may be related to poor living conditions and poor hygiene habits