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作者研究了钙拮抗剂替帕米(Tiapamil)长期(1年)降压效果和安全性。 20例轻、中度原发性高血压患者(卧位舒张压95～115mmHg),服安慰剂2周后开始口服替帕米,起始量每日600mg(分2次);无效时在4周内逐渐增加至每日900mg,极量每日1200mg,分2次口服。确定合适剂量后连续治疗52周。25周末突然停药3日,观察有无血压回升;然后再继续治疗。总疗程共58周。 10例于替帕米治疗6周内血压恢复正常(卧位舒张压≤95mmHg),其中7例
The authors studied the long-term (1 year) antihypertensive efficacy and safety of the calcium antagonist Tiapamil. 20 patients with mild to moderate essential hypertension (supine diastolic blood pressure 95 ~ 115mmHg), taking placebo 2 weeks after oral tepamil, the initial daily dose of 600mg (2 times); invalid in 4 Week gradually increased to 900mg daily, extremely daily 1200mg, 2 times orally. After determining the appropriate dose for 52 weeks. 25 weekend sudden withdrawal on the 3rd, observe whether the blood pressure rise; and then continue treatment. The total duration of treatment was 58 weeks. In 10 cases, the blood pressure returned to normal within 6 weeks of treatment (supine diastolic pressure ≤95mmHg), of which 7