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目的探讨各年龄组血清抗苗勒管激素水平(AMH)在体外受精-胚胎移植(IVF-ET)或卵母细胞浆内单精子显微注射(ICSI)治疗过程和结局的相关性。方法将169例首次应用Gn RH-a短效制剂长方案促排卵行IVF-ET或ICSI的患者,根据年龄分为A组:24~30岁(n=49);B组:31~35岁(n=59);C组:36~40岁(n=47);D组:41~45岁(n=14),比较4组AMH水平,窦卵泡数、获卵数,妊娠率等相关参数,并进行分析。结果各组窦卵泡数、获卵数、优胚数、移植胚胎数、冷冻胚胎数均无统计学差异(P>0.05);AMH水平在A组与D组存在统计学差异(P<0.05);A组与其他三组在妊娠率均有统计学差异(P<0.05),B组与D组在妊娠率上也有统计学差异(P<0.05)。结论年龄是预测卵巢储备和卵巢反应性的首选和粗标准,但将年龄作为一个独立指标来预测卵巢储备功能并不可靠,应结合AMH水平综合评估。年龄是预测卵子质量的独立指标,估计预后是比较合理的。
Objective To investigate the correlation between serum anti-Mulhirrg hormone levels (AMH) and IVF-ET or intracytoplasmic sperm injection (ICSI) in all age groups. Methods A total of 169 patients with IVF-ET or ICSI who were ovariectomized for the first time with short-term GnRH-a short-acting formulation were divided into three groups according to their ages: group A (24-30 years) (n = 49), group B (n = 59), group C: 36-40 years old (n = 47), group D: 41-45 years old (n = 14). The AMH level, the number of antral follicles, the number of oocytes retrieved, Parameters, and analysis. Results There were no significant differences in the number of antral follicles, number of oocytes retrieved, number of excellent embryos, number of embryos transferred and number of frozen embryos in each group (P> 0.05). There was a significant difference in AMH between group A and group D (P <0.05) There were significant differences in pregnancy rates between group A and the other three groups (P <0.05). There was also a significant difference in pregnancy rates between group B and group D (P <0.05). Conclusion Age is the preferred and crude standard for predicting ovarian reserve and ovarian response. However, age as an independent index to predict ovarian reserve function is not reliable and should be combined with comprehensive assessment of AMH levels. Age is an independent predictor of egg quality, and prognosis is more reasonable.