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内源性和外源性环腺苷和腺苷环核苷酸类似物对胃窦胃泌素释放的刺激作用已经在体外应用灌注技术、组织培养和器官培养所阐明。现已证明,钙可刺激人体胃泌素释放和胃的分泌,但钙对基础和环核苷酸间介的胃窦胃泌素释放的影响以及双价离子载体A23187对胃泌素分泌效应的研究尚未见报道。本文研究主要目的在于检测不同钙浓度对有或无DBCAMP(双丁酰环腺苷)培养基中的鼠胃窦粘膜植片释放胃泌素的效果。
Stimulation of gastric gastrin release by endogenous and exogenous cyclic adenosine and adenosine cyclic nucleotide analogs has been demonstrated in vitro by perfusion techniques, tissue culture and organ culture. It has been demonstrated that calcium stimulates the release of human gastrin and the secretion of the stomach, but the effect of calcium on the release of gastrulin between the basic and cyclic nucleotide intermediates and the effect of the bivalent ionophore A23187 on gastrin secretion Research has not been reported yet. The main purpose of this study was to examine the effect of different concentrations of calcium on the release of gastrin from gastric antral mucosal grafts in DBCAMP (dibutyrylcyanide) medium.