论文部分内容阅读
目的:探讨十二指肠溃疡(DU)患者CD4、CD8 T细胞亚群的改变及其临床意义。方法:采用流式细胞术检测DU患者外周血T淋巴细胞亚群。结果:39例DU患者与正常对照组比较CD3差异无显著性,CD4、CD4/CD8比值显著降低(P<0.01),而CD8明显升高(P<0.01);洛赛克、克拉霉素和替硝唑三联方案治疗后CD4、CD4/CD8比值较治疗前明显升高(P<0.01),而CD8明显降低(P<0.01)。结论:T淋巴细胞亚群的变化可能在DU的发生、发展中发挥了重要作用,DU的发生、发展及预后与机体免疫功能状态密切相关。
Objective: To investigate the changes of CD4 and CD8 T cell subsets in patients with duodenal ulcer (DU) and its clinical significance. Methods: T lymphocyte subsets in peripheral blood of patients with DU were detected by flow cytometry. Results: There was no significant difference in CD3 between the 39 DU patients and the normal controls (P <0.01), while the CD8 was significantly increased (P <0.01) The ratio of CD4 and CD4 / CD8 after treatment with tinidazole triple therapy was significantly higher than that before treatment (P <0.01), while CD8 was significantly decreased (P <0.01). CONCLUSION: The changes of T lymphocyte subsets may play an important role in the occurrence and development of DU. The occurrence, development and prognosis of DU are closely related to the status of immune function.