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目的:比较新柏氏电脑辅助系统(TIS)阅片与单纯人工阅片两种方法在宫颈癌细胞学筛查中的效率、灵敏度和准确性。方法:分别统计单纯人工阅片组和TIS辅助阅片组的每例用时、阳性检出率、活检诊断相符率。结果:总计收集42 430例液基薄层细胞学检测病例,其中单纯人工阅片25 808例,TIS辅助阅片16 622例,数据显示TIS:(1)平均58.9 s·片-1(每小时约60张玻片),较单纯人工阅片效率提高40%~250%;(2)ASCUS及以上的总阳性检出率、ASCUS、ASC-H和HSIL检出率分别为8.02%、5.43%、0.17%、0.63%,均高于单纯人工阅片,各组差异有统计学意义(P<0.05);(3)经活检证实,TIS与人工阅片相比各组诊断相符率差异无统计学意义。结论:TIS明显缩短了医生阅片的筛查时间;在检测宫颈鳞状上皮病变时TIS优于人工阅片,其敏感度提高不以损失特异度来实现。
OBJECTIVE: To compare the efficiency, sensitivity and accuracy of two TIS readings and one manual reading in cervical cytology screening. Methods: We counted the positive rate and the coincidence rate of biopsy in every case of simple radiography group and TIS-assisted radiotherapy group respectively. RESULTS: A total of 42 430 cases of liquid-based lamellar cytology were collected. Among them, 25 808 cases of pure manual radiographs and 16 622 cases of TIS auxiliary radiographs were collected. The data showed that TIS: (1) averaged 58.9 s -1 About 60 slides), which was 40% ~ 250% higher than that of simple manual radiography. (2) The positive rates of ASCUS and above, the positive rates of ASCUS, ASC-H and HSIL were 8.02% and 5.43% , 0.17%, 0.63%, respectively, which were higher than that of simple radiographs. The difference between the two groups was statistically significant (P <0.05). (3) Significance of learning. Conclusion: TIS significantly shortens the screening time of doctors’ readings. TIS is superior to manual radiographs in detecting squamous cell carcinoma of the cervix, and its sensitivity can be improved without loss of specificity.