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目的 :观察四联 (果胶铋、阿莫西林、甲硝唑、奥美拉唑 )一周疗法和三联 (果胶铋、阿莫西林、甲硝唑 )两周疗法对幽门螺杆菌 (Hp)的根除效果及安全性。方法 :79例胃粘膜Hp阳性的十二指肠溃疡患者随机分入四联组 (42例 )和三联组 (37例 ) ,Hp根除和溃疡愈合均以停药 4周后胃镜复查为准。结果 :四联组Hp根除率 90 5 %、溃疡愈合率 83 3% ,而三联组则分别为 83 8%、78 4% ,但无统计学差异。四联组副作用(2 8 6 % )少于三联组 (32 4% ) ,差别无显著性。结论 :三联和四联疗法均对Hp阳性的十二指肠溃荡有效 ,而四联疗法可获得高的Hp根除率 ,且疗程短 ,价格较便宜 ,可优先选用。
Objective: To observe the effects of four weeks (pectin bismuth, amoxicillin, metronidazole and omeprazole) and three weeks (bismuth pectate, amoxicillin and metronidazole) two weeks treatment on Helicobacter pylori (Hp) Eradication and safety. Methods: A total of 79 gastric mucosal Hp-positive duodenal ulcer patients were randomly divided into quadruple group (42 cases) and triple group (37 cases). Hp eradication and ulcer healing were controlled by endoscopy after 4 weeks’ withdrawal. Results: The Hp eradication rate was 95.5% and the ulcer healing rate was 83.3% in the quadruple group, while 83.8% and 78.4% in the triad group, respectively, but no significant difference was found. The quadruple group had fewer side effects (286%) than the triple group (32.4%), with no significant difference. CONCLUSION: Both triple and quadruple therapy are effective for Hp-positive duodenal ulcer, and quadruple therapy can achieve high Hp eradication rate, and the treatment is short, the price is cheaper, which may be preferred.