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目的 探讨活血化瘀法治疗红斑狼疮的实验依据及讨论这些实验变化与红斑狼疮虚证之间的关系。方法 测定 83例红斑狼疮患者 6项血液流变学指标 ,对 2 0例甲皱毛细血管进行微循环观察。结果 红斑狼疮患者 6项血液流变学指标中各项与正常人对照组比较有显著异常。 2 0例甲皱毛细血管镜检微循环有不同程度障碍。结论 在用活血化瘀中草药治疗红斑狼疮时若结合辨证选择适当性味的活血化瘀药物治疗当可进一步提高疗效。微循环观察及血液物化指标测定也有助于红斑狼疮辩证分型参考及治疗的客观评价指标之一。
Objective To investigate the experimental basis for the treatment of lupus erythematosus by promoting blood circulation and removing blood stasis and to discuss the relationship between these experimental changes and the deficiency syndrome of lupus erythematosus. Methods Six hemorheological indexes were determined in 83 patients with lupus erythematosus. Microcirculation was observed in 20 cases of Achilles capillaries. Results Six of the six hemorheological parameters in patients with lupus were significantly abnormal compared with the normal control group. 20 cases of nail fold capillary microscopy have different degrees of microcirculation. Conclusion In the treatment of lupus erythematosus with Chinese herbal medicine for promoting blood circulation and removing blood stasis, it is possible to further improve the curative effect by combining the traditional Chinese medicine of promoting blood circulation and removing blood stasis when selecting proper taste. Microcirculation observation and determination of blood physical and chemical indicators also contribute to dialectical reference and treatment of lupus and one of the objective evaluation indicators.