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目的观察知柏地黄口服液联合西医常规疗法治疗甲状腺功能亢进的临床疗效。方法将166例患者随机分为治疗组和对照组各83例,两组均予丙硫氧嘧啶、心得安治疗,治疗组同时加用知柏地黄口服液;治疗12周后观察临床疗效、丙硫氧嘧啶用药减量及实验室指标变化情况。结果治疗组、对照组总有效率分别为96.3%和83.8%;组间疗效比较,差异有统计学意义(P<0.05)。治疗组丙硫氧嘧啶减量情况优于对照组(P<0.01),两组治疗后均心率减慢(P<0.01),FT3、FT4水平下降(P<0.05,P<0.01),TSH水平上升(P<0.01);组间治疗后比较,差异均有统计学意义(P<0.05,P<0.01)。结论知柏地黄口服液联合西药治疗甲状腺功能亢进有较好的临床疗效,可明显降低有关实验室指标,有效减少基础用药剂量。
Objective To observe the clinical efficacy of Zhibai Dihuang Oral Liquid combined with conventional western medicine in the treatment of hyperthyroidism. Methods 166 patients were randomly divided into treatment group and control group of 83 cases, both groups were treated with propylthiouracil, propranolol treatment, the treatment group plus Zhibai Dihuang liquid; 12 weeks after treatment to observe the clinical efficacy of C Sulfathiazide dosage reductions and laboratory changes in indicators. Results The total effective rates in the treatment group and the control group were 96.3% and 83.8%, respectively. There were significant differences in the efficacy between the two groups (P <0.05). The reduction of propylthiouracil in the treatment group was better than that in the control group (P <0.01). The heart rate of both groups were decreased (P <0.01), the levels of FT3 and FT4 decreased (P <0.05, P <0.01) (P <0.01). After treatment, the differences were statistically significant (P <0.05, P <0.01). Conclusion Zhibai Dihuang combined with western medicine in the treatment of hyperthyroidism has a good clinical efficacy, can significantly reduce the relevant laboratory indicators, effectively reducing the basic dosage.