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目的：研究部分肝切除（ＰＨ）对大鼠肝癌模型肿瘤生长的影响，并初步探讨其可能机制。方法：建立大鼠肝癌模型后，施行不同比例的部分肝切除，观察肿瘤生长变化，通过检测其细胞、体液免疫功能及免疫抑制因子变化，以初步探讨其可能机制。结果：部分肝切除后，接种的肿瘤随肝切除比例增加而生长明显加速，细胞免疫功能抑制程度随之加重，肝部分切除组血清ｓＩＬ－２Ｒ、ＴＧＦ－β、ＩＬ－１０在术后早期即与对照组具有显著差异。结论：ＰＨ能刺激接种肿瘤生长，可能与ＰＨ后免疫功能受抑、肝再生致细胞因子分泌异常等有关。
Objective: To study the effect of partial hepatectomy (PH) on the growth of rat hepatoma model and to explore its possible mechanism. METHODS: After rat hepatoma model was established, different proportions of partial hepatectomy were performed to observe the changes of tumor growth. The changes of cellular and humoral immune functions and immunosuppressive factors were detected to explore possible mechanisms. RESULTS: After partial hepatectomy, the inoculated tumors accelerated significantly as the proportion of hepatic resection increased, and the degree of inhibition of cellular immune function aggravated. Serum sIL-2R, TGF-beta, and IL-10 in the hepatectomy group were early in the surgery. There was a significant difference from the control group. Conclusion: PH can stimulate the growth of tumor inoculation, which may be related to the suppression of immune function after PH, abnormal secretion of cytokines caused by liver regeneration and so on.