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目的:探讨生长分化因子15(GDF15)在118例胃癌组织的表达及其临床意义。方法:应用免疫组化法分别检测118例胃癌组织和96例癌旁正常组织中GDF15的表达。结果:免疫组化法结果显示,GDF15在胃癌组织中的阳性表达率为85.8%(97/113),明显低于癌旁正常组织表达率95.8%(92/96),两者比较差异有统计学意义,P=0.014。GDF15蛋白的表达与胃癌Lauren分型(χ2=7.758,P=0.005)和组织学分级(χ2=4.598,P=0.032)有关,与胃癌患者年龄(χ2=2.906,P=0.088)、性别(χ2=0.125,P=0.723)、肿瘤长径大小(χ2=0.254,P=0.614)、肿瘤临床分期(χ2=0.125,P=0.723)和有无淋巴结转移(χ2=1.139,P=0.286)无关。结论:GDF15在胃癌组织中低表达,并且与胃癌Lauren分型和组织学分级密切有关。
Objective: To investigate the expression of GDF15 in 118 cases of gastric carcinoma and its clinical significance. Methods: The expression of GDF15 in 118 cases of gastric cancer tissues and 96 cases of adjacent normal tissues was detected by immunohistochemistry. Results: Immunohistochemistry results showed that the positive rate of GDF15 in gastric cancer was 85.8% (97/113), which was significantly lower than that in adjacent normal tissues (95.8%, 92/96). The difference was statistically significant Significance of learning, P = 0.014. GDF15 protein expression was correlated with Lauren classification (χ2 = 7.758, P = 0.005) and histological grade (χ2 = 4.598, P = 0.032) (Χ2 = 0.125, P = 0.723), with or without lymph node metastasis (χ2 = 1.139, P = 0.286). Conclusion: GDF15 is lowly expressed in gastric cancer tissues and is closely related to Lauren classification and histological grade of gastric cancer.