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运用病例对照研究方法，探讨乙型肝炎病毒宫内感染的主要危险因素及机制。共调查３５０例ＨＢｓＡｇ阳性孕妇及其新生儿，ＨＢＶ感染血清学标志用酶联免疫吸附法检测。调查资料经单因素和多因素Ｌｏｇｉｓｔｉｃ回归模型分析。结果表明，母亲ＨＢｅＡｇ阳性、先兆早产史是宫内感染的危险因素，其ＯＲ值分别为４．６４（２．７９～６．４８）和５．２２（３．１２～７．３２）。
The use of case-control study to explore the main risk factors and mechanisms of hepatitis B virus intrauterine infection. A total of 350 HBsAg positive pregnant women and their newborns were investigated. Serological markers of HBV infection were detected by enzyme-linked immunosorbent assay. Survey data by single factor and multivariate Logistic regression model analysis. The results showed that maternal HBeAg-positive, threatened preterm birth is a risk factor for intrauterine infection, the OR values were 4.64 (2.79 ~ 6.48) and 5.22 (3.12 ~ 7.32) respectively.